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pcaveney

Sapere Aude: Dare to Know

Graduate School

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Bredesen Center for Interdisciplinary Research and Graduate Education

I am a PhD student at the University of Tennessee, Knoxville and Oak Ridge National Laboratory with a Bredesen Center Fellowship. I research noise in protein expression at under the guidance of my advisors Mike Simpson in the DOE sponsored Center for Nanophase Material Science and Mitch Doktycz in BioSciences Division.

Cell-sized, cell-free reactions are increasing in complexity and imitating many functions of living cells. They have membranes, the ability to make proteins, form pores, grow, metabolize glucose, and communicate with cells. However making protein, the basis for every living cell, is highly variable in these reactions. Identically prepared reactions often show order of magnitude differences in the amount of protein made chamber-to-chamber. Understanding the causes of this variability will allow greater functionality for cell-sized, cell-free reactions.

I became interested in biology and genetics after creating transgenic, green fluorescent bacteria in high school AP biology. As an undergraduate junior, I worked with Dr. Mingjun Zhang to model the Young’s modulus of a silicone matrix filled with dispersed nanoparticles. Senior year, I worked with Dr. Cong Trinh to create a collection of plasmids with different copy numbers and antibiotic resistances. These plasmids were then incorporated into other work being done in the lab for better control over enzyme production and the associated metabolic processes. I graduated with a Bachelor of Science in Biomedical Engineering with a minor in Engineering Entrepreneurship from the University of Tennessee, Knoxville.

My ORNL profile is here. 

My Google Scholar profile is here.


Awards:

2018 Extraordinary Professional Promise - Chancellor’s Citation Awards - Chancellor’s Honors Banquet

Bredesen Center Energy Science Engineering Fellowship

Summa cum laude 2013

Deans list Fall 2009 - Spring 2013

Alcoa Engineering Study Abroad Fellow

Tau Beta Pi member


Research Publications:

Norred, S. Elizabeth, Patrick M. Caveney, Gaurav Chauhan, Lauren K. Collier, C. Patrick Collier, Steven M. Abel, and Michael L. Simpson. "Macromolecular Crowding Induces Spatial Correlations That Control Gene Expression Bursting Patterns." ACS synthetic biology 7, no. 5 (2018): 1251-1258.

Boreyko, Jonathan, P. Caveney, Sarah L. Norred, Charles Chin, Scott T. Retterer, Michael L. Simpson, and C. Pat Collier. "Synthetic Biology in Aqueous Compartments at the Micro-and Nanoscale." MRS Advances 2, no. 45 (2017): 2427-2433.

Caveney, Patrick M., S. Elizabeth Norred, Charles W. Chin, Jonathan B. Boreyko, Brandon S. Razooky, Scott T. Retterer, C. Patrick Collier, and Michael L. Simpson. "Resource Sharing Controls Gene Expression Bursting." ACS Synthetic Biology (2016). [PDF]

Norred, S. E., Caveney, P. M., Retterer, S. T., Boreyko, J. B., Fowlkes, J. D., Collier, C. P., et al. Sealable Femtoliter Chamber Arrays for Cell-free Biology. J. Vis. Exp. (97), e52616, doi:10.3791/52616 (2015).

Lijin Xia, Zhonghua Xu, Leming Sun, Patrick M. Caveney, Mingjun Zhang. (2013) “Nano-fillers to tune Young's modulus of silicone matrix.” Journal of Nanoparticle Research. v. 15 pg. 1570. [PDF]


Graduate Courses Taken

LFSC 507 - Programming for Biological Data Analysis

STAT 537 - Statistics for Research I

ESE 597 Bioenergy Journal Club

MSE 578 Advanced Biomaterials/Nanomaterials

PHYS 642 BioPhysics

ESE 697 Stochastic Processes Bio/Sys

CBE 691 Biomolecular Kinetics and Cellular Dynamics

MATH 527 Stochastic Modeling

ESE 593 Independent Study

ESE 593 Independent Study: Entrepreneurship

ESE 593 Entrepreneurship Studies

ESE 511 Introduction to Energy Science & Technology I

ESE 512 Introduction to Energy Science & Technology II


July 09, 2014

POSTDOC SYMPOSIUM

July 09, 2014/ Patrick Caveney

I presented a poster titled “Noise Analysis of Confined Cell-free Protein Production” at the second annual Oak Ridge National Lab Postdoc Symposium on July 9, 2014.

July 09, 2014/ Patrick Caveney/ Comment

Patrick Caveney

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Featured
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Sep 10, 2019
ORNL Review
Sep 10, 2019
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Jun 29, 2019
SEED 2019
Jun 29, 2019
Jun 29, 2019
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May 11, 2019
Graduation
May 11, 2019
May 11, 2019
Apr 15, 2019
Dissertation
Apr 15, 2019
Apr 15, 2019
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Apr 12, 2019
Membrane Transport
Apr 12, 2019
Apr 12, 2019
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Apr 10, 2019
Membrane Permeability
Apr 10, 2019
Apr 10, 2019
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Mar 28, 2019
Dissertation Defense
Mar 28, 2019
Mar 28, 2019
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Jan 13, 2017
Gordon Conference
Jan 13, 2017
Jan 13, 2017
Oct 1, 2016
Resource Sharing
Oct 1, 2016
Oct 1, 2016
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Jul 22, 2016
SEED 2016
Jul 22, 2016
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Jun 13, 2015
SEED 2015
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Mar 11, 2015
JOVE
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Nov 14, 2014
SynBioBeta 2014
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Sep 16, 2014
CNMS User Meeting
Sep 16, 2014
Sep 16, 2014
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Jul 9, 2014
POSTDOC SYMPOSIUM
Jul 9, 2014
Jul 9, 2014
Aug 30, 2013
Caltech Workshop
Aug 30, 2013
Aug 30, 2013
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pcaveney

The personal website of Patrick Caveney.

@pcaveney

  • RT @mcjpod: New CTSS episode is out, with @bova_fett from @mobiuspbc! Awesome startup that partners with companies generating… https://t.co/1hYNZLijMk
    Sep 10, 2020, 12:16 PM
 

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